Microbiological Characteristics Of The Oral Mucosain Patients With Lichen Planus Erythematosus

Abstract

Lichen planus is a multifactorial disease that involves immune, neuroendocrine, microbiological, and other metabolic processes associated with skin and mucosal damage.

          The microflora of the oral cavity in CPL SOPR was studied by E. S. Leontieva etal., 2014, the microbiocenosis of various biotopes of the oral cavity in patients with CPL SOPR was studied. The study involved 95 patients with CPL SOPR, who underwent hygienic, periodontal and microbiological research methods. The results of the degree of bacterial contamination indicate a more pronounced colonization of foci of CPL lesion by representatives of the coccoid flora: Streptococcus salivares and Streptococcus mutans, but there is no correlation between them. Isolated Streptococcus Sanguis colonies were observed in 55% of patients. In addition, fungi of the genus Candida albicans were detected in 50%, the average level of adhesion of Candida albicans strains in patients with CPL was 16.78±1.64%. The frequency of detection of fungi of the genus Candida albicans in foci of CPL lesion correlates (r=0.79) with the activity of the disease course. The significance of Candida albicans contamination is determined not so much by the degree of contamination of the lesion foci, but by such pathogenic properties of Candida albicansas the level of adhesion and the activity of germination tubes formation [1,2,3,6,11,2,3,6,11].

          Authors Chuikin S. V., Akmalova G. M., Chernysheva N. D., 2014, analyzed the qualitative and quantitative microbiocenosis of the oral cavity in patients with CPL. The study included 145 patients with CPL aged 21 to 76 years, of whom 5% were men and 95% were women. The predominant form of CPL was erosive-ulcerative form (33.1%), the lowest frequency was observed in 2% of patients with bullous form. The results of the study showed that dysbiotic changes were observed with a predominance of candida infection and were found in 57.2% of the examined patients, which are observed more often in erosive-ulcerative and bullous forms of CPL. The results of the study showed that all the examined patients had microbiocenosis disorders of varying severity from dysbiotic shift to IYgrade IY dysbiosis and high sensitivity to bacteriophages was revealed. It should be noted that high sensitivity of pathogenic and opportunistic microorganisms sown in дисбактериозахoral dysbiosis was detected to цефалоспориногоcephalosporin antibiotics (100%), oxacillin (79%), gentamicin (76%), lincomycin (73%).  [5,7,9,12].

 A number of foreign authors Villa (TG, Sá ncheznchez-Pérez rez Á, Sieiro C., 2021) believe that microbial infection triggers an autoimmune response. Withdysbiosisof the intestinal microbiota , there is a violationof the integrity of the intestinal barrier, followed by an increase in intestinal permeability, and the penetration микроорганизмof microorganisms and their toxinов into the circulatory system. Current knowledge about this disease requires the inclusion of this disease in the list of autoimmune diseases, since the progression of CPL involves colonization of locally affected areas by bacteria, fungi or viruses that occur after damage to the oral mucosa and skin. The process of healing the disease should include eliminating microbial dysbiosis and restoring the normal microbiota of the oral mucosa, skin, and intestines. [4,6,8,10,13,14]. 

Keywords:

lichen planus, microbiocenosis

References

Leontieva E. S. et al. On the issue of microbial contamination of lesions of the oral mucosa with lichen planus erythematosus //Practical medicine. - 2014. - t. 1. – №. 4 (80). – P. 59-64.

Leontieva E. K. Stomatological manifestations of lichen planus and prognostic significance of factors influencing its course: АвторефAbstract of the dissertation.... candidate of Medical Sciences. Kazan, 2014, 24 p. (in Russian)

Letaeva, O. V. Clinical and pathogenetic characteristics of patients with lichen planus erythematosus and justification авторефof therapy. дис ... candidate of medical sciences / O. V. Letaeva. Yekaterinburg, 2012, 27 p. (in Russian)

Evaluation of the composition of the microbiota of the oral cavity, small and large intestine in patients with lichen planus of the oral mucosa: Russian-Chinese Congress on Medical Microbiology, Epidemiology and Clinical Mycology (XX Kashkin Readings): abstracts of reports / E. D. Surdina [et al.] / / Problems of medical mycology. - 2017. - Volume 19, N2. - pp. 141-142

Chuikin S. V., Akmalova G. M., Chernysheva N. D. Characteristics of the oral microflora in patients with lichen planus erythematosus.Periodontology. 2014. Vol. 19, no. 4, pp.41-43.

Villa TG, Sánchez-Pérez Á, Sieiro C. Oral lichen planus: a microbiologist point of view. Int Microbiol. 2021 Aug;24(3):275-289.

Rodriguez-Archilla A, Fernandez-Torralbo S. Candida species colonization in oral lichen planus: A meta-analysis. Int J Health Sci (Qassim). 2022 Jul-Aug;16(4):58-63.

Gupta, S. Oral lichen planus: An update on etiology, pathogenesis, clinical presentation, diagnosis and management / S. Gupta, M. K. Jawanda // Indian J Dermatol. – 2015.– №60. – P. 222–229

Gümrü B. A. Retrospective study of 370 patients with oral lichen planus in

Turkey / B. A. Gümrü // Med Oral Patol Oral Cir Bucal. – 2013. – V. 18, N 3. –

e427-432.

González-Moles MÁ, Warnakulasuriya S, González-Ruiz I, Ayén Á, González-Ruiz L, Ruiz-Ávila I, Ramos-García P. Dysplasia in oral lichen planus: relevance, controversies and challenges. A position paper. Med Oral Patol Oral Cir Bucal. 2021 Jul 1;26(4):e541-e548.

Fitzpatrick, S. G. The malignant transformation of oral lichen planus and oral lichenoid lesions: a systematic review / S. G. Fitzpatrick, S. A. Hirsch, S. C. Gordon // J Am Dent Assos. – 2014. – Vol. 145 (1). – P. 45–56;

Fernanda Mombrini Pigatti , Luis Antonio de Assis Taveira, Cleverson Teixeira Soaris. Immunohistochemical expression of Bcl-2 and Ki-67 in oral lichen planus and leukoplakia with varying degrees of dysplasia. Accessories to expand. Int J Dermatol.February 2015;54(2):150-5.

Baek K, Choi Y. The microbiology of oral lichen planus:Is microbial infection the cause of oral lichen planus? Mol Oral Microbiol. 2018;33:22–8.

Bombeccari GP, Gianni AB, Spadari F. Oral Candida colonization and oral lichen planus. Oral Dis. 2017;23:1009–10. [PubMed] [Google Scholar]