DECIPHERING CELL SIGNALING PATHWAYS IN ORAL CANCER: A COMPREHENSIVE REVIEW

Abstract

Oral cancer is a significant public health concern, with a complex pathogenesis involving dysregulated cell signaling pathways. Understanding the molecular mechanisms underlying oral cancer development and progression is crucial for improving diagnostic and therapeutic approaches. This comprehensive review aims to decipher the intricate cell signaling pathways involved in oral cancer. Various key signaling pathways, including the PI3K/Akt, MAPK, Wnt/β-catenin, and Notch pathways, among others, are explored in the context of oral cancer pathogenesis. The review delves into the crosstalk between these pathways and their influence on tumor growth, invasion, angiogenesis, and resistance to therapies. By providing a comprehensive overview of cell signaling alterations in oral cancer, this review offers valuable insights for the development of targeted therapies and personalized treatment strategies to combat this devastating disease effectively.

Keywords:

Oral cancer, cell signaling pathways, pathogenesis

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