Chilling Consequences: Investigating Offspring Brain Oxidative Changes Due to Maternal Hypothermia in Gestational Diabetic Rats

Abstract

 

"Chilling Consequences: Investigating Offspring Brain Oxidative Changes Due to Maternal Hypothermia in Gestational Diabetic Rats" explores the consequential effects of maternal hypothermia during pregnancy in gestational diabetic rats, focusing on its impact on the oxidative status of the offspring's brain. This research investigates the potential links between maternal hypothermia, oxidative stress, and neurodevelopmental outcomes in the offspring. By unveiling the intricate dynamics at play, this study sheds light on the implications of maternal conditions on offspring brain health.

Keywords:

Maternal hypothermia, Gestational diabetes, Offspring brain, Oxidative changes, Neurodevelopment, Oxidative stress, Gestational conditions

References

• Negrato CA, Mattar R, Gomes MB. Adverse pregnancy outcomes in women with diabetes. Diabetol Metab Syndr 2012;4:41.

• Verburg PE, Tucker G, Scheil W, Erwich JJ, Dekker GA, Roberts CT. Seasonality of gestational diabetes mellitus: A South Australian population study. BMJ Open Diab Res Care 2016;4:e000286.

• McCormack C, Leemaqz S, Furness D, Dekker G, Roberts CT. Do raised two-hour pre-pregnancy insulin levels confer the same risks of developing GDM, as raised fasting levels, in recurrent miscarriage patients? J Obstet Gynaecol 2019;2:1-5.

• Utz B, Delamou A, Belaid L, De Brouwere V. Detection and management of diabetes during pregnancy in low resource settings: Insights into past and present clinical practices. J Diab Res 2016;2016:1-14.

• Jain R, Pathak RR, Kotecha AA. Gestational diabetes: Perinatal and maternal complication in 24-28 weeks. Int J Med Sci Public Health 2014;3:1283-8.

• Ma S, Morilak DA. Chronic intermittent cold stress sensitises the hypothalamic-pituitary-adrenal response to a novel acute stress by enhancing noradrenergic influence in the rat paraventricular nucleus. J Endocrinol 2005;17:761-9.

• DeMorrow S. Role of the hypothalamic-pituitary-adrenal axis in health and disease. Int J Mol Sci 2018;19:986.

• Hanssen MJ, Hoeks J, Brans B, van der Lans AA, Schaart G, van den Driessche JJ, et al. Short-term cold acclimation improves insulin sensitivity in patients with Type 2 diabetes mellitus. Nat Med 2015;21:863-5.

• Benedict CR, Fillenz M, Stanford C. Noradrenaline release in rats during prolonged cold-stress and repeated swim-stress. Br J Pharmacol 1979;66:521-4.

• Pacak K, Palkovits M, Yadid G, Kvetnansky R, Kopin IJ, Goldstein DS. Heterogeneous neurochemical responses to different stressors: A test of Selye’s doctrine of nonspecificity. Am J Physiol 1998;275:R1247-55