Autoimmune Disorders Unraveled: The Interplay Between Genetics and the Immune System.

Esra Hassan  Abd Ali; Hussain Owaid  Mohammed

doi:10.55640/ijmsdh-10-03-18

Open Access

Autoimmune Disorders Unraveled: The Interplay Between Genetics and the Immune System.

Vol. 10 No. 03 (2024): Volume 10 Issue 03 | Pages: 01-14 | https://doi.org/10.55640/ijmsdh-10-03-18

Authors

Esra Hassan Abd Ali
Basic Science Department, Dentistry college, Mustansiriyah University, Baghdad-Iraq.
https://orcid.org/0000-0002-2143-1809

Hussain Owaid Mohammed
Oral surgery and Periodontology Department, Dentistry college, Mustansiriyah University, Baghdad-Iraq.
https://orcid.org/0000-0001-8520-0068

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Published Date: 2024-03-04
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How to Cite

Abd Ali, E. H. ., & Mohammed, H. O. . (2024). Autoimmune Disorders Unraveled: The Interplay Between Genetics and the Immune System. International Journal of Medical Science and Dental Health, 10(03), 01-14. https://doi.org/10.55640/ijmsdh-10-03-18

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Abstract

Autoimmune diseases are a group of disorders that have an abnormal immune response against the owner’s tissues. Another key feature in the pathogenesis of these diseases is an interaction between genetics and environment. Although the emergence of a number of recent genomic technologies has simplified establishing many susceptibility genes and loci that determine an inherited predisposition to autoimmunity, The goal of this review article is to explore the element of complexity that stems from correlation between genetics and immunity when focusing autoimmune diseases. It provides major genetic differences that define immune cell activity, mechanisms related to the regulation of self-tolerance and inflammatory reactions. Also, the review describes epigenetic modifications that could modify gene expression and behavior of immune systems causing disease development or progression. In this chapter, using GWAS as well as other types of genetic studies we address how these recent advances in genetics have improved our understanding of disease mechanisms and enabled the development of novel strategies for personalizing therapeutic interventions. This paper further explores the opportunities such genetic findings present in creating predictive models for disease risk assessment and as a prescription to personalized medicine. The understanding and control of autoimmunity will greatly benefit from unraveling the genetic complexities involved in these conditions.

References

Castro C, Gourley M. Diagnostic testing and interpretation of tests for autoimmunity. J Allergy Clin Immunol. 2010;125(2 Suppl 2):S238-47.

Vojdani A, Vojdani E, Rosenberg AZ, Shoenfeld Y. The Role of Exposomes in the Pathophysiology of Autoimmune Diseases II: Pathogens. Pathophysiology. 2022;29(2):243-80.

Janeway Jr CA, Travers P, Walport M, Shlomchik MJ. Autoimmune responses are directed against self antigens. Immunobiology: The Immune System in Health and Disease 5th edition: Garland Science; 2001.

Lucas CL, Lenardo MJ. Identifying genetic determinants of autoimmunity and immune dysregulation. Curr Opin Immunol. 2015;37:28-33.

Jörg S, Grohme DA, Erzler M, Binsfeld M, Haghikia A, Müller DN, et al. Environmental factors in autoimmune diseases and their role in multiple sclerosis. Cell Mol Life Sci. 2016;73(24):4611-22.

Mohammed ZJ, Sharba MM, Mohammed AA. THE EFFECT OF CIGARETTE SMOKING ON HAEMATOLOGICAL PARAMETERS IN HEALTHY COLLEGE STUDENTS IN THE CAPITAL, BAGHDAD. European Journal of Molecular & Clinical Medicine

Gregersen PK, Olsson LM. Recent advances in the genetics of autoimmune disease. Annu Rev Immunol. 2009;27:363-91.

Cárdenas-Roldán J, Rojas-Villarraga A, Anaya JM. How do autoimmune diseases cluster in families? A systematic review and meta-analysis. BMC Med. 2013;11:73.

Lettre G, Rioux JD. Autoimmune diseases: insights from genome-wide association studies. Hum Mol Genet. 2008;17(R2):R116-21.

Cruz-Tapias P, Castiblanco J, Anaya J-M. HLA association with autoimmune diseases. Autoimmunity: From Bench to Bedside [Internet]: El Rosario University Press; 2013.

Anaya J-M, Castiblanco J, Lessard CJ. Non-HLA genes and autoimmune diseases. Autoimmunity: From Bench to Bedside [Internet]: El Rosario University Press; 2013.

Pisetsky DS. Pathogenesis of autoimmune disease. Nature Reviews Nephrology. 2023;19(8):509-24.

Mohammed M, Al-Saadi MS, Al-Karawi AS. An examination of the seroprevalence of torch infections and their correlation with adverse reproductive outcomes in females exhibiting a bad obstetric history.

Popoviciu MS, Kaka N, Sethi Y, Patel N, Chopra H, Cavalu S. Type 1 Diabetes Mellitus and Autoimmune Diseases: A Critical Review of the Association and the Application of Personalized Medicine. J Pers Med. 2023;13(3).

Al-Karawi AS, Alawssi YF, Khadhum MK. Immunological Insights into Rheumatoid Arthritis: A Comprehensive Review of Diagnosis and Assessment Approaches. African Journal of Advanced Pure and Applied Sciences (AJAPAS). 2023:151-9.

Kready HO, Mohammed M, Salem M, Al-Karwi AS. SCREENING AND DIAGNOSIS OF BETA-THALASSEMIA DEPENDING ON HBA2 AND BLOOD FILM IN BAGHDAD CITY. World. 2023;2(6).

Moulton VR, Suarez-Fueyo A, Meidan E, Li H, Mizui M, Tsokos GC. Pathogenesis of Human Systemic Lupus Erythematosus: A Cellular Perspective. Trends Mol Med. 2017;23(7):615-35.

Karawi A, Kadhim A. Exploring the role of autoantibodies in Iraqi females with polycystic ovary syndrome. J Adv Biotechnol Exp Ther. 2024;7(1):147.

Pollard KM, Hultman P, Kono DH. Toxicology of autoimmune diseases. Chem Res Toxicol. 2010;23(3):455-66.

Alajeeli FS, Al-Karawi AS, Ali MM. The Immunological Significance of Medicinal Plants in Disease Control and Prevention in Humans. Al-Salam Journal for Medical Science. 2023;2(2):13-9.

Ashok T, Patni N, Fatima M, Lamis A, Siddiqui SW. Celiac Disease and Autoimmune Thyroid Disease: The Two Peas in a Pod. Cureus. 2022;14(6):e26243.

Júnior DST. Environmental and individual factors associated with protection and predisposition to autoimmune diseases. Int J Health Sci (Qassim). 2020;14(6):13-23.

Al-Karawi AS, Atoom AM, Al-Adwan SM, Adwan SW. Assessment of selected biochemical and immunological parameters after treatment by Cosmetic Procedures. Journal of Population Therapeutics and Clinical Pharmacology. 2023;30(2):201-13.

Mousa WK, Chehadeh F, Husband S. Microbial dysbiosis in the gut drives systemic autoimmune diseases. Front Immunol. 2022;13:906258.

Estadt SN, Maz MP, Musai J, Kahlenberg JM. Mechanisms of Photosensitivity in Autoimmunity. J Invest Dermatol. 2022;142(3 Pt B):849-56.

Olivieri B, Betterle C, Zanoni G. Vaccinations and Autoimmune Diseases. Vaccines (Basel). 2021;9(8).

MOHAMMED M, Mousa D, Tareq Jafaar Al-Jindeel H, Al-Karawi S. Latent and reactivation Cytomegalovirus (CMV) infection can cause severe fetal sequelae despite pre-conceptional immunity.

Al-Karawi AS, Abid FM, Mustafa A, Abdulla M. Revealing the Urinary Microbiota in Prostate Cancer: A Comprehensive Review Unveiling Insights into Pathogenesis and Clinical Application. Al-Salam Journal for Medical Science. 2024;3(1):45-54.

Mazzone R, Zwergel C, Artico M, Taurone S, Ralli M, Greco A, et al. The emerging role of epigenetics in human autoimmune disorders. Clinical Epigenetics. 2019;11(1):34.

Choo SY. The HLA system: genetics, immunology, clinical testing, and clinical implications. Yonsei Med J. 2007;48(1):11-23.

Kurkó J, Besenyei T, Laki J, Glant TT, Mikecz K, Szekanecz Z. Genetics of rheumatoid arthritis - a comprehensive review. Clin Rev Allergy Immunol. 2013;45(2):170-9.

Ahmed MH, Karkush SI, Ali SA, Mohammed AA. Phytochemicals: a new arsenal in drug discovery. International Journal of Medical Science and Dental Health. 2024;10(01):29-44.

Gutierrez-Arcelus M, Rich SS, Raychaudhuri S. Autoimmune diseases - connecting risk alleles with molecular traits of the immune system. Nat Rev Genet. 2016;17(3):160-74.

Surace AEA, Hedrich CM. The Role of Epigenetics in Autoimmune/Inflammatory Disease. Front Immunol. 2019;10:1525.

Araki Y, Mimura T. The Mechanisms Underlying Chronic Inflammation in Rheumatoid Arthritis from the Perspective of the Epigenetic Landscape. J Immunol Res. 2016;2016:6290682.

Liu R, Wu J, Guo H, Yao W, Li S, Lu Y, et al. Post-translational modifications of histones: Mechanisms, biological functions, and therapeutic targets. MedComm (2020). 2023;4(3):e292.

De Benedittis G, Ciccacci C, Latini A, Novelli L, Novelli G, Borgiani P. Emerging Role of microRNAs and Long Non-Coding RNAs in Sjögren's Syndrome. Genes (Basel). 2021;12(6).

Ho SM, Johnson A, Tarapore P, Janakiram V, Zhang X, Leung YK. Environmental epigenetics and its implication on disease risk and health outcomes. Ilar j. 2012;53(3-4):289-305.

Al-Azzawi MA, Maftool AJ, Al-Shimary AA, Mohammed AA. A Comprehensive Review of Vitamin D3: Metabolism, Functions, and Clinical Implications. International Journal of Medical Science and Dental Health. 2023;9(12):37-46.

Van Kaer L. Major histocompatibility complex classI‐restricted antigen processing and presentation. Tissue antigens. 2002;60(1):1-9.

Mohammed AA, Mahmoud HQ, Mhana RS. ADVANCES IN THE DIAGNOSIS AND MANAGEMENT OF BREAST CANCER: A SYSTEMATIC REVIEW. World. 2023;2(6).

Mahmoud HQ, Mhana RS, Mohammed AA. Therapeutic options and management approach on thalassemia an overview. International Journal of Medical Science and Dental Health. 2024;10(01):17-28.

Gavali LV, Mohammed AA, Al-Ogaili MJ, Gaikwad SH, Kulkarni M, Das R, et al. Novel terephthalaldehyde bis (thiosemicarbazone) Schiff base ligand and its transition metal complexes as antibacterial Agents: Synthesis, characterization and biological investigations. Results in Chemistry. 2024;7:101316.

Crux NB, Elahi S. Human Leukocyte Antigen (HLA) and Immune Regulation: How Do Classical and Non-Classical HLA Alleles Modulate Immune Response to Human Immunodeficiency Virus and Hepatitis C Virus Infections? Front Immunol. 2017;8:832.

Kloypan C, Koomdee N, Satapornpong P, Tempark T, Biswas M, Sukasem C. A Comprehensive Review of HLA and Severe Cutaneous Adverse Drug Reactions: Implication for Clinical Pharmacogenomics and Precision Medicine. Pharmaceuticals (Basel). 2021;14(11).

Mogensen TH. Pathogen recognition and inflammatory signaling in innate immune defenses. Clin Microbiol Rev. 2009;22(2):240-73, Table of Contents.

Lourenço EV, La Cava A. Natural regulatory T cells in autoimmunity. Autoimmunity. 2011;44(1):33-42.

Giovannetti A, Pierdominici M, Di Iorio A, Cianci R, Murdaca G, Puppo F, et al. Apoptosis in the homeostasis of the immune system and in human immune mediated diseases. Curr Pharm Des. 2008;14(3):253-68.

Knight JC. Genomic modulators of the immune response. Trends Genet. 2013;29(2):74-83.

Theofilopoulos AN, Kono DH, Baccala R. The multiple pathways to autoimmunity. Nat Immunol. 2017;18(7):716-24.

Ko DK, Brandizzi F. Network-based approaches for understanding gene regulation and function in plants. Plant J. 2020;104(2):302-17.

Ford K, McDonald D, Mali P. Functional Genomics via CRISPR-Cas. J Mol Biol. 2019;431(1):48-65.

Fenton KA, Pedersen HL. Advanced methods and novel biomarkers in autoimmune diseases ‑ a review of the recent years progress in systemic lupus erythematosus. Front Med (Lausanne). 2023;10:1183535.

Pascual V, Chaussabel D, Banchereau J. A genomic approach to human autoimmune diseases. Annu Rev Immunol. 2010;28:535-71.