The relationship between Fatty Acids and Type II Diabetes Mellitus

Safa Khudair; Lubna Faisal Hussein; Shahad Imad Hameed; Maha khalid khadhum; Saif Ali Mohammed Hussein

doi:10.55640/ijmsdh-10-07-05

Open Access

The relationship between Fatty Acids and Type II Diabetes Mellitus

Vol. 10 No. 07 (2024): Volume 10 Issue 07 | Pages: 39-47 | https://doi.org/10.55640/ijmsdh-10-07-05

Authors

Safa Khudair
Department of Biology, College of Sciences, University of Baghdad, Baghdad, Iraq .

Lubna Faisal Hussein
Department of Biology, College of Sciences, University of Baghdad, Baghdad, Iraq.

Shahad Imad Hameed
Department of Biology, College of Sciences, University of Baghdad, Baghdad, Iraq.

Maha khalid khadhum
Ibn Sina University of Medical and Pharmaceutical Sciences, Baghdad, Iraq.

Saif Ali Mohammed Hussein
MedicaL laboratory Techniques. Dijlah University College.

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Published Date: 2024-07-27
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How to Cite

Khudair, S., Hussein, L. F., Hameed, S. I., khadhum, M. khalid, & Hussein, S. A. M. (2024). The relationship between Fatty Acids and Type II Diabetes Mellitus. International Journal of Medical Science and Dental Health, 10(07), 39-47. https://doi.org/10.55640/ijmsdh-10-07-05

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Abstract

We can summarize the main risk factors for type 2 diabetes mellitus (T2DM) by looking at our nutrition, age, and lifestyle. β-cell dysfunction and insulin resistance (IR) are outcomes of the pathophysiology of type 2 diabetes. As an indirect result of IR on important metabolic enzymes, lipid and lipoprotein abnormalities are also a factor in T2DM patients. Recent research has indicated that lipid fluctuation may be the cause of poor glucose metabolism as well as one of its effects. Fatty acids (FAs) affect cell membrane fluidity and permeability, insulin receptor binding and signaling, and the translocation of glucose transporters. Therefore, it is suggested that FAs might play a crucial part in the emergence of IR and T2DM. The current review's objective was to

References

- DeFronzo, R. A., Ferrannini, E., Groop, L., Henry, R. R., Herman, W. H., Holst, J. J., ... & Weiss, R. (2015). Type 2 diabetes mellitus. Nature reviews Disease primers, 1(1), 1-22.

- Chatterjee, S., Khunti, K., & Davies, M. J. (2017). Type 2 diabetes. The lancet, 389(10085), 2239-2251.

- Hu, F. B., Van Dam, R. M., & Liu, S. (2001). Diet and risk of type II diabetes: the role of types of fat and carbohydrate. Diabetologia, 44, 805-817.

- Azevedo M, Alla S. Diabetes in sub-saharan Africa: kenya, mali, mozambique, Nigeria, South Africa and zambia. Int J Diabetes Dev Ctries 2008. Oct;28(4):101-108 10.4103/0973-3930.45268

- Chamnan P, Simmons RK, Forouhi NG, Luben R. Khaw Ky, Wareham NJ et al. Incidence of type 2 diabetes using proposed HbA1c diagnostic criteria in the EPIC-Norflok cohort: Implication for preventive strategies

- Zimmet P, Alberti KG, Shaw J. Global and societal implications of the diabetes epidemic. Nature 2001. Dec;414(6865):782-787 10.1038/414782a

- Ripsin CM, Kang H, Urban RJ. Management of blood glucose in type 2 diabetes mellitus. Am Fam Physician 2009. Jan;79(1):29-36

- Hu FB, Manson JE, Stampfer MJ, Colditz G, Liu S, Solomon CG, et al. Diet, lifestyle, and the risk of type 2 diabetes mellitus in women. N Engl J Med 2001. Sep;345(11):790-797 10.1056/NEJMoa010492

- Prevalence of overweight and obesity among adults with diagnosed Diabetes United States, 1988-1994 and 1999-2000"Centers for Disease Control and Prevention (CDC) (November 2004) MMWR. Morbidity and Mortality Weekly Report; 53(45): 1066-1068

- Barlow SE and the Expert Committee Expert committee recommendations regarding the prevention, assessment and treatment of childhood and adolescent overweight and obesity: Summary report. Paediatrics 2007;120: S164-S192. 10.1542/peds.2007-2329C

- Rother KI. Diabetes treatment–bridging the divide. N Engl J Med 2007. Apr;356(15):1499-1501 10.1056/NEJMp078030

- McCarthy MI. Genomics, type 2 diabetes, and obesity. N Engl J Med 2010. Dec;363(24):2339-2350 10.1056/NEJMra0906948

- Walley AJ, Blakemore AI, Froguel P. Genetics of obesity and the prediction of risk for health. Hum Mol Genet 2006. Oct;15(Spec No 2): R124-R130 10.1093/hmg/ddl215

- Camastra S, Bonora E, Del Prato S, Rett K, Weck M, Ferrannini E, EGIR (European Group for the Study of Insulin Resistance) Effect of obesity and insulin resistance on resting and glucose-induced thermogenesis in man. Int J Obes Relat Metab Disord 1999. Dec;23(12):1307-1313 10.1038/sj.ijo.0801072

- Alberti KG, Zimmet P, Shaw J, IDF Epidemiology Task Force Consensus Group The metabolic syndrome–a new worldwide definition. Lancet 2005. Sep;366(9491):1059-1062 10.1016/S0140-6736(05)67402-8

- Powers AC. Diabetes mellitus. In: Fauci AS, Braunwauld E, Kasper DL, Hauser SL, Longo DL, Jameson JL, Loscalzo J (eds). Harrison’s Principles of Internal Medicine.17th ed, New York, McGraw-Hill; 2008: 2275-2304. [

- Jack L, Jr, Boseman L, Vinicor F. Aging Americans and diabetes. A public health and clinical response. Geriatrics 2004. Apr;59(4):14-17

- Lovejoy JC. The influence of dietary fat on insulin resistance. Curr Diab Rep 2002. Oct;2(5):435-440 10.1007/s11892-002-0098-y

- Boden, G., & Shulman, G. I. (2002). Free fatty acids in obesity and type 2 diabetes: defining their role in the development of insulin resistance and β‐cell dysfunction. European journal of clinical investigation, 32, 14-23.

- Garcia-Roves PM. Mitochondrial pathophysiology and type 2 diabetes mellitus. Arch Physiol Biochem 2011. Jul;117(3):177-187 10.3109/13813455.2011.584538

- Cox EM, Elelman D. Test for screening and diagnosis of type 2 diabetes. Clin Diabetes 2009;4(27):132-138. 10.2337/diaclin.27.4.132

- Harris MI, Klein R, Welborn TA, Knuiman MW. Onset of NIDDM occurs at least 4-7 yr before clinical diagnosis. Diabetes Care 1992. Jul;15(7):815-819 10.2337/diacare.15.7.815

- International Expert Committee International Expert Committee report on the role of the A1C assay in the diagnosis of diabetes. Diabetes Care 2009; 32:1-8. 10.2337/dc09-S001

- Kamble, S. A., Barale, S. S., Mohammed, A. A., Paymal, S. B., Naik, N. M., & Sonawane, K. D. (2024). Structural insights into the potential binding sites of Cathepsin D using molecular modelling techniques. Amino Acids, 56(1), 33.

- van de Laar F, van de Lisdonk E, Lucassen P, Tigchelaar J, Meyboom S, Mulder J, van den Hoogen H, Rutten G, van Weel C. Fat intake in patients newly diagnosed with type 2 diabetes: a 4-year follow-up study in general practice. Br J Gen Pract. 2004; 54:177–182.

- Borkman M, Storlien LH, Pan DA, Jenkins AB, Chisholm DJ, Campbell LV. The relation between insulin sensitivity and the fatty-acid composition of skeletal-muscle phospholipids. N Engl J Med. 1993; 328:238–244.

- Pan DA, Lillioja S, Milner MR, Kriketos AD, Baur LA, Bogardus C, Storlien LH. Skeletal muscle membrane lipid composition is related to adiposity and insulin action. J Clin Invest. 1995; 96:2802–2808.

- Salmeron J, Hu FB, Manson JE, Stampfer MJ, Colditz GA, Rimm EB, Willett WC. Dietary fat intake and risk of type 2 diabetes in women. Am J Clin Nutr. 2001; 73:1019–1026.

- Meyer KA, Kushi LH, Jacobs DR, Jr, Folsom AR. Dietary fat and incidence of type 2 diabetes in older Iowa women. Diabetes Care. 2001; 24:1528–1535.

- Mozaffarian D. Trans fatty acids - effects on systemic inflammation and endothelial function. Atheroscler Suppl. 2006; 7:29–32.

- Smedman AE, Gustafsson IB, Berglund LG, Vessby BO. Pentadecanoic acid in serum as a marker for intake of milk fat: relations between intake of milk fat and metabolic risk factors. Am J Clin Nutr. 1999; 69:22–29.

- Hodge AM, English DR, O'Dea K, Sinclair AJ, Makrides M, Gibson RA, Giles GG. Plasma phospholipid and dietary fatty acids as predictors of type 2 diabetes: interpreting the role of linoleic acid. Am J Clin Nutr. 2007; 86:189–197.

- Pereira MA, Jacobs DR, Jr, Van Horn L, Slattery ML, Kartashov AI, Ludwig DS. Dairy consumption, obesity, and the insulin resistance syndrome in young adults: the CARDIA Study. Jama. 2002; 287:2081–2089.

- Liu S, Choi HK, Ford E, Song Y, Klevak A, Buring JE, Manson JE. A prospective study of dairy intake and the risk of type 2 diabetes in women. Diabetes Care. 2006; 29:1579–1584.

- Mohammed, A. A., & Sonawane, K. D. (2022). Destabilizing Alzheimer's Aβ42 protofibrils with oleocanthal: In-silico approach. BIOINFOLET-A Quarterly Journal of Life Sciences, 19(3), 288-295.

- Pinhas-Hamiel, O. & Zeitler, P. The global spread of type 2 diabetes mellitus in children and adolescents. J. Pediatr. 146, 693–700 (2005)

- Liese, A. D. et al. The burden of diabetes mellitus among US youth: prevalence estimates from the SEARCH for Diabetes in Youth Study.Pediatrics 118, 1510–1518 (2006).

- Kitagawa, T., Owada, M., Urakami, T. &Yamauchi, K. Increased incidence of non-insulin dependent diabetes mellitus among Japanese schoolchildren correlates with an increased intake of animal protein and fat. Clin. Pediatr. (Phila.) 37, 111–115 (1998).

- Craig, M. E., Femia, G., Broyda, V., Lloyd, M. & Howard, N. J. Type 2 diabetes in Indigenous and non-Indigenous children and adolescents in New South Wales. Med. J. Aust. 186, 497–499 (2007).

- Dabelea, D. et al. Association testing of TCF7L2 polymorphisms with type 2 diabetes in multi- ethnic youth. Diabetologia 54, 535–539 (2011).

- Williams, D. E. et al. Prevalence of impaired fasting glucose and its relationship with cardiovascular disease risk factors in US adolescents, 1999–2000. Pediatrics 116, 1122–1126 (2005).

- Li, C., Ford, E. S., Zhao, G. & Mokdad, A. H. Prevalence of pre-diabetes and its association with clustering of cardiometabolic risk factors and hyperinsulinemia among U.S. adolescents: National Health and Nutrition Examination Survey 2005–2006. Diabetes Care 32, 342–347 (2009).

- Rokholm, B., Baker, J. L. & Sorensen, T. I. The levelling off of the obesity epidemic since the year 1999—a review of evidence and perspectives. Obes. Rev. 11, 835–846 (2010).

- Mokdad, A. H. et al. Diabetes trends in the U.S.: 1990–1998. Diabetes Care 23, 1278–1283 (2000).

- Lawrence, J. M. et al. Diabetes in Hispanic American youth: prevalence, incidence, demographics, and clinical characteristics: the SEARCH for Diabetes in Youth Study. Diabetes Care 32 (Suppl. 2), S123–S132 (2009).

- Mahmoud, H. Q., Mhana, R. S., & Mohammed, A. A. (2024). Therapeutic options and management approach on thalassemia an overview. International Journal of Medical Science and Dental Health, 10(01), 17-28.

- American Diabetes Association. Standards of medical care in diabetes–2010. Diabetes Care 33 (Suppl. 1), S11–S61 (2010).

- World Health Organization. Use of glycated haemoglobin (HbA1c) in the diagnosis of diabetes mellitus: abbreviated report of a WHO consultation [online], http://www.who.int/ diabetes/publications/report-hba1c_2011.pdf (2011).

- Selvin, E. et al. Glycated hemoglobin, diabetes, and cardiovascular risk in nondiabetic adults. N. Engl. J. Med. 362, 800–811 (2010).

- Santos-Oliveira, R. et al. Haemoglobin A(1c) levels and subsequent cardiovascular disease in persons without diabetes: a meta-analysis of prospective cohorts. Diabetologia 54, 1327–1334 (2011).

- Al-Azzawi, M. A., Maftool, A. J., Al-Shimary, A. A., & Mohammed, A. A. (2023). A Comprehensive Review of Vitamin D3: Metabolism, Functions, and Clinical Implications. International Journal of Medical Science and Dental Health, 9(12), 37-46.

- Zhou, X. et al. Performance of an A1C and fasting capillary blood glucose test for screening newly diagnosed diabetes and pre-diabetes defined by an oral glucose tolerance test in Qingdao, China. Diabetes Care 33, 545–550 (2010).

- Selvin, E., Zhu, H. & Brancati, F. L. Elevated A1C in adults without a history of diabetes in the U.S. Diabetes Care 32, 828–833 (2009).

- Mohan, V. et al. A1C cut points to define various glucose intolerance groups in Asian Indians. Diabetes Care 33, 515–519 (2010).

- Al-Musawi, A. H. O., Aziz, H. M., Khudair, S., & Saleh, T. H. (2022). Molecular characterization of HBB gene mutations in beta-thalassemia patients of Southern Iraq. Biomedicine, 42(5), 1040-1043.

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