Harnessing the Microbiome: Probiotic Mechanisms of Action and Therapeutic Potential

Marwah A.  Alshafeay; Suadad Taha Al- Masoodi; Saif Ali Mohammed

doi:10.55640/ijmsdh-11-04-05

Open Access

Harnessing the Microbiome: Probiotic Mechanisms of Action and Therapeutic Potential

Vol. 11 No. 04 (2025): Volume 11 Issue 04 | Pages: 43-51 | https://doi.org/10.55640/ijmsdh-11-04-05

Authors

Marwah A. Alshafeay
Dijlah University college/ Department of Medical Laboratory Techniques

Suadad Taha Al- Masoodi
Dijlah University college/ Department of Medical Laboratory Techniques

Saif Ali Mohammed
Dijlah University college/ Department of Medical Laboratory Techniques

Views: 29 Downloads: 32
Google Scholar

Published Date: 2025-04-13
Download PDF: pdf

Copyright License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors retain the rights to their work published in the International Journal of Medical Science and Dental Health and may republish or reproduce their own work, provided proper citation to the original publication in IJMSDH is included.

How to Cite

Harnessing the Microbiome: Probiotic Mechanisms of Action and Therapeutic Potential. (2025). International Journal of Medical Science and Dental Health, 11(04), 43-51. https://doi.org/10.55640/ijmsdh-11-04-05

More Citation Formats

Download Citation

Downloads

Download data is not yet available.

Abstract

The clinical interest in probiotics as live microorganisms continues to rise because these microorganisms deliver health benefits at suitable dose ranges. Probiotics were first applied for gastrointestinal disorders but scientists now investigate their ability to affect mental health alongside metabolic diseases and skin conditions and cardiovascular health.

The human body obtains various advantages from these microorganisms which consist of maintaining microbial equilibrium and reinforcing immune responses along with gut wall function and generating SCFAs and other beneficial metabolites. The medical application of these bacteria shows promise although their appropriate strain selection faces delivery difficulties and certain population groups face ongoing safety concerns. The study will investigate customized therapeutic uses of probiotics together with synbiotics and analyze their effects on disease control methods and disease prevention strategies. Modern technological applications of probiotics demonstrate strong potential for disease prevention as well as health enhancement.

References

Aggarwal N, Kitano S, Puah GRY, Kittelmann S, Hwang IY, Chang MW. Microbiome and Human Health: Current Understanding, Engineering, and Enabling Technologies. Chem Rev. 2023;123(1):31-72.

Oelschlaeger TA. Mechanisms of probiotic actions–a review. International journal of medical microbiology. 2010;300(1):57-62.

Mohammed, Z. J., Sharba, M. M., & Mohammed, A. A. (2022). The effect of cigarette smoking on haematological parameters in healthy college students in the capital, baghdad. European Journal of Molecular & Clinical Medicine, 9(3), 11013-11022.

Nithya A, Misra S, Panigrahi C, Dalbhagat CG, Mishra HN. Probiotic potential of fermented foods and their role in non-communicable diseases management: An understanding through recent clinical evidences. Food Chemistry Advances. 2023; 3:100381.

Mohammed, A. A., & Sonawane, K. D. (2022). Destabilizing Alzheimer's Aβ42 protofibrils with oleocanthal: In-silico approach. BIOINFOLET-A Quarterly Journal of Life Sciences, 19(3), 288-295.

Portincasa P, Bonfrate L, Vacca M, De Angelis M, Farella I, Lanza E, et al. Gut Microbiota and Short Chain Fatty Acids: Implications in Glucose Homeostasis. Int J Mol Sci. 2022;23(3).

Mahmoud, H. Q., Mhana, R. S., & Mohammed, A. A. (2024). Therapeutic options and management approach on thalassemia an overview. International Journal of Medical Science and Dental Health, 10(01), 17-28.

Mohammed, A. A., Mahmoud, H. Q., & Mhana, R. S. (2023). Advances in the diagnosis and management of breast cancer: a systematic review. World, 2(6).

Gilbert JA, Blaser MJ, Caporaso JG, Jansson JK, Lynch SV, Knight R. Current understanding of the human microbiome. Nature medicine. 2018;24(4):392-400.

Hussein, A. F., Khamees, H. H., Mohammed, A. A., Hussein, S. A. M., Ahmed, M. A., Saad, A., & Raoof, M. In-Silico Study Of Destabilizing Alzheimer’s Aβ42 Protofibrils With Curcumin.

Deo PN, Deshmukh R. Oral microbiome: Unveiling the fundamentals. J Oral Maxillofac Pathol. 2019;23(1):122-8.

Sedghi L, DiMassa V, Harrington A, Lynch SV, Kapila YL. The oral microbiome: Role of key organisms and complex networks in oral health and disease. Periodontol 2000. 2021;87(1):107-31.

Li X, Liu Y, Yang X, Li C, Song Z. The Oral Microbiota: Community Composition, Influencing Factors, Pathogenesis, and Interventions. Front Microbiol. 2022; 13:895537.

Santacroce L, Passarelli PC, Azzolino D, Bottalico L, Charitos IA, Cazzolla AP, et al. Oral microbiota in human health and disease: A perspective. Exp Biol Med (Maywood). 2023;248(15):1288-301.

Mark Welch JL, Ramírez-Puebla ST, Borisy GG. Oral Microbiome Geography: Micron-Scale Habitat and Niche. Cell Host & Microbe. 2020;28(2):160-8.

Di Stefano M, Polizzi A, Santonocito S, Romano A, Lombardi T, Isola G. Impact of Oral Microbiome in Periodontal Health and Periodontitis: A Critical Review on Prevention and Treatment. Int J Mol Sci. 2022;23(9).

Latif A, Shehzad A, Niazi S, Zahid A, Ashraf W, Iqbal MW, et al. Probiotics: mechanism of action, health benefits and their application in food industries. Front Microbiol. 2023; 14:1216674.

Zendeboodi F, Khorshidian N, Mortazavian AM, da Cruz AG. Probiotic: conceptualization from a new approach. Current Opinion in Food Science. 2020; 32:103-23.

Wang X, Zhang P, Zhang X. Probiotics Regulate Gut Microbiota: An Effective Method to Improve Immunity. Molecules. 2021;26(19).

Chandrasekaran P, Weiskirchen S, Weiskirchen R. Effects of Probiotics on Gut Microbiota: An Overview. Int J Mol Sci. 2024;25(11).

Mazziotta C, Tognon M, Martini F, Torreggiani E, Rotondo JC. Probiotics Mechanism of Action on Immune Cells and Beneficial Effects on Human Health. Cells. 2023;12(1).

Gou HZ, Zhang YL, Ren LF, Li ZJ, Zhang L. How do intestinal probiotics restore the intestinal barrier? Front Microbiol. 2022; 13:929346.

Yang SC, Lin CH, Sung CT, Fang JY. Antibacterial activities of bacteriocins: application in foods and pharmaceuticals. Front Microbiol. 2014; 5:241.

Markowiak-Kopeć P, Śliżewska K. The Effect of Probiotics on the Production of Short-Chain Fatty Acids by Human Intestinal Microbiome. Nutrients. 2020;12(4).

Ansari F, Neshat M, Pourjafar H, Jafari SM, Samakkhah SA, Mirzakhani E. The role of probiotics and prebiotics in modulating of the gut-brain axis. Front Nutr. 2023; 10:1173660.

Tahseen, T. H. (2019). The impact of the educational method using the training method in some physical variables of the muscles of the limbs and the strength of the transmissions in the game of tennis. University of Anbar Sport and Physical Education Science Journal, 4(18).

Bizzini B, Pizzo G, Scapagnini G, Nuzzo D, Vasto S. Probiotics and oral health. Curr Pharm Des. 2012;18(34):5522-31.

Tahseen, T. H. (2022). The effect of using master learning in a changing exercise style for some tennis skills of young people. Sciences Journal Of Physical Education, 15(2).

Ursell LK, Metcalf JL, Parfrey LW, Knight R. Defining the human microbiome. Nutrition reviews. 2012;70(suppl_1):S38-S44.

Dawood, I. R. A., & Tahseen, T. H. (2024). Examination Of The Use Of Picture Card Technology To Help Elementary School Students Develop Their Basketball Skills. International Journal Of Cognitive Neuroscience And Psychology, 2(2), 1-7.

Didari T, Mozaffari S, Nikfar S, Abdollahi M. Effectiveness of probiotics in irritable bowel syndrome: Updated systematic review with meta-analysis. World J Gastroenterol. 2015;21(10):3072-84.

Jandhyala SM, Talukdar R, Subramanyam C, Vuyyuru H, Sasikala M, Nageshwar Reddy D. Role of the normal gut microbiota. World J Gastroenterol. 2015;21(29):8787-

Tahseen, T. H., Jawad, K. A. H., Dakhil, H. O., Khamis, H., & Abbas, S. (2024). The effectiveness of attention and kinesthetic awareness and their relationship to the accuracy of performing the forehand and backhand stroke in badminton. Sciencia Journal, 1, 77-85.