Pathogenesis And Antibiotic Resistance of Neisseria Gonorrhoeae: A Review Article

Abstract

Neisseria gonorrhoeae is a major public health problem. Rising prevalence and increasing antibiotic resistance in this organism make a growing concern. Timely treatment and management of infections depend on better understanding its microbiological features and effective diagnostic methodologies. Neisseria gonorrhoeae, the etiologic agent of gonorrhea, is an important sexually transmitted infection (STI). The pathophysiology of infections due to N. gonorrhoeae describes interaction of the bacterium with host defense mechanisms that result in various clinical manifestations. Neisseria gonorrhoeae has almost continuously over the last decades been a significant public health challenge increasing infection rates and rising antibiotic resistance. Hence updated protocols for therapy as recently guidelines recommended based upon research findings. This paper shall carry an integrative appraisal of recent works related to the microbiological traits of N. gonorrhoeae, the competence of current diagnostic measures, and the menace brought by antimicrobial resistance. It carries an integrative appraisal of existing research findings on the pathogenesis of N. gonorrhoeae with a focus on its infection mechanisms, antimicrobial resistance, and implications for treatment. This paper shall carry another integrative appraisal of existing perceptions concerning the antimicrobial treatment of infections caused by N. gonorrhoeae with a focus on challenges from patterns of resistance, adequacy levels of existing regimens, and possible future directions in research.

Keywords:

Pathogenesis, treatment approaches, Neisseria gonorrhea

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