Iron Dysregulation in Sickle Cell Disease: Trend and Clinical Implications

Dr. Bashir Abdrhman Bashir

doi:10.55640/ijmsdh-11-10-10

Open Access

Iron Dysregulation in Sickle Cell Disease: Trend and Clinical Implications

Vol. 11 No. 10 (2025): Volume 11 Issue 10 | Pages: 93-100 | https://doi.org/10.55640/ijmsdh-11-10-10

Authors

Dr. Bashir Abdrhman Bashir
Associate Professor of Hematology / Consultant of Medical Laboratory Sciences Port Sudan Ahlia University, Faculty of Medical Laboratory Sciences, Port Sudan, Sudan
https://orcid.org/0000-0002-5089-9531

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Published Date: 2025-10-18
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Dr. Bashir Abdrhman Bashir. (2025). Iron Dysregulation in Sickle Cell Disease: Trend and Clinical Implications. International Journal of Medical Science and Dental Health, 11(10), 93-100. https://doi.org/10.55640/ijmsdh-11-10-10

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Abstract

Iron imbalance in sickle cell disease (SCD) is a complex puzzle that leads to persistent hemolysis, recurrent transfusions, and dysregulated iron metabolism. This brief review examines the key trends in iron homeostasis, overload, and deficiency in SCD, exploring the underlying mechanisms, clinical implications, and therapeutic approaches. Iron overload frequently arises from transfusion therapy, although iron shortage may also result from heightened erythropoietic demand and inflammation. We highlight the functions of serum ferritin, transferrin saturation (TSAT), hepcidin, and new biomarkers, as well as therapeutic strategies encompassing chelation and innovative treatments. This review synthesizes current findings, identifies knowledge gaps, and suggests future research directions to enhance iron-related outcomes in sickle cell disease (SCD).

Keywords:

Sickle cell disease, iron overload, iron deficiency, transfusion, chelation therapy, hemolysis, Iron, Ferritin, TSAT

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Iron Dysregulation in Sickle Cell Disease: Trend and Clinical Implications

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Dr. Bashir Abdrhman Bashir

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