Serum Potassium, Phosphate, and Calcium Levels and Their Correlation with eGFR in Patients with Chronic Kidney Diseas

Abstract

A chronic kidney disease (CKD) is a persistent disease that is associated with kidney functions and the corresponding electrolyte homeostasis imbalance. The study was aimed to compare the serum background levels of potassium, phosphate and calcium in CKD patients versus healthy controls and provide the association between each and estimated glomerular filtration rate (eGFR). Seventy study participants were recruited including fifty CKD patients and twenty of controls. Serum electrolytes were identified with the help of traditional biochemical methods, eGFR was estimated with the help of CKD-EPI formula. The results indicated that the potassium and phosphate levels were very high and calcium was very low in CKD patients in comparison to controls (p < 0.05). Also, eGFR was negatively correlated with potassium and phosphate and positively correlated with calcium, which indicates that electrolyte imbalances increase with a decreating renal condition. These studies indicate that monitoring of electrolytes in serum ought to be done as an indicator of the degree of the disease and metabolic complications in CKD.

Keywords:

CKD, eGFR, Potassium, Phosphate, Calcium

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