The Utility of Serum CD152 Concentration as a Differential Biomarker in Hashimoto's Thyroiditis

Abstract

Background: Hashimoto's disease is an autoimmune disorder that affects the thyroid gland. The thyroid gland, shaped like a butterfly, is located at the base of the neck, directly beneath the Adam's apple. The thyroid produces hormones that help to regulate a variety of body processes. An autoimmune illness occurs when the immune system attacks healthy tissues. In Hashimoto's disease, immune system cells cause the death of thyroid hormone-producing cells. Hypothyroidism is a common consequence of the condition.

Objectives: Aim of study is to investigating the levels of CD152 and its correlation TSH, T3 and T4 to provide the reference for the diagnosis of Hashimoto's.

Materials and Methods: This study included (80 patients “40 males and 40 females” with Hashimoto's and 40 healthy persons as control group). Five ml of blood were taken from all to assess T3, T4, TSH, Vitamin D and CD152 according to procedures that provide with kits. By SPSS v.29, all data were analyzed at P value equal or less than 0.5.

Results: The level of CD152 is higher in female group when compare with male group P- value 0.05, the ROC carve show the CD152 is greater than vitamin D and TSH and more specific to distinguish between the groups, In Hashimoto's thyroiditis patients, there was a link between CD152 and thyroid function tests. 

Conclusion: It was concluding CD152 is depend alone is a novel biomarker to HT diagnosis, in addition there is correlation between CD152 and TSH, T3, T4.

Keywords:

Hashimoto’s, CD152, autoimmune disease, TSH, T3

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