Clinical and Laboratory Markers of The Development and Progression of Renal Damage in Patients with Systemic Scleroderma

Abstract

To Studying the clinical and laboratory signs of the development and progression of kidney damage in patients with systemic scleroderma is an urgent scientific and practical task. Investigating the clinical and laboratory markers of scleroderma nephropathy not only allows for a deeper understanding of the mechanisms of kidney damage in systemic scleroderma, but also improves early diagnosis, disease activity monitoring, disease course prediction, and the individualization of therapeutic and preventive measures.

Keywords:

Systemic scleroderma, scleroderma nephropathy, laboratory markers

References

Dolgova E.A. Risk factors for the development and progression of kidney damage in patients with systemic scleroderma // Candidate of Medical Sciences dissertation. Russia. Orenburg. - 2013. - 260 p. (in Russian)

Nasonova E.L. Rheumatology: clinical recommendations // M.: GEOTAR - Media, 2020. - P. 523-557.

Maurizio C., Stefano S., Vanessa S. Pathophysiology of systemic sclerosis: current understanding and new insights // Expert Review of Clinical Immunology. – 2019. -№ 15:7. –Р. 753-764

Servais A., Giral P., Bernard M. et al.Is serum cystatin-C a reliable marker for metabolic syndrome ? // Am. J. Med. - 2018. - Vol.121, N.5. - P.426-432.

Sobanski V., Giovannelli J., Allanore Y., Riemekasten G., Airò P., Vettori S., Cozzi F., Distler O., Matucci-Cerinic M., Denton C. et al. Phenotypes Determined by Cluster Analysis and Their Survival in the Prospective European Scleroderma Trials and Research Cohort of Patients with Systemic Sclerosis. // Arthritis Rheumatol. – 2019. - № 71. –Р. 1553–1570.

Sterner G., Bjork J., Carlson J. et al. Validation of a new plasma cystatin C-based formula and the Modification of Diet in Renal Disease creatinine-based formula for determination of glomerular filtration rate // Scand. J. Urol. Nephrol. - 2019. - Vo.43, N.3. - P. 242-249.

Watad A., Rosenberg V., Tiosano S. et al. Silicone breast implants and the risk of autoimmune/rheumatic disorders: a real-world analysis // Int J Epidemiol. – 2018. – № 47. – P. 1846–1854.

Wigley F.M., Flavahan N.A. Raynaud’s Phenomenon // N. Engl J Med. – 2016. - № 375. – P. 556–565.