Adjunctive Biocompatible Film and Laser Therapy for Oral Mucosal Trophic Ulcers: A Comparative Clinical Study

Abstract

Background: Persistent oral mucosal ulcers require etiologic assessment and treatment of local and systemic contributing factors. Biocompatible films and low intensity laser therapy may offer complementary approaches to wound management, but comparative clinical evidence for lesions classified as trophic ulcers is limited.

Objective: To compare ulcer epithelialization time after conventional comprehensive treatment with that after comprehensive treatment supplemented by a biocompatible film and laser irradiation.

Methods: A single center comparative clinical study was conducted in Tashkent, Uzbekistan, during 2022–2025. Fifty-five patients were treated with adjunctive Novacel Ziyo film followed by laser irradiation (n = 28) or conventional comprehensive therapy (n = 27). Twenty healthy participants provided laboratory reference measurements. Epithelialization time was the principal outcome of this manuscript. Salivary immune and blood endothelial markers were examined as exploratory outcomes. The present draft uses aggregate results; allocation procedures, uncertainty estimates, and several laboratory entries require confirmation from original records.

Results: Reported epithelialization time was 6.8 ± 0.3 days in the adjunctive group and 11.2 ± 0.4 days in the conventional group, with ranges of 5–10 and 8–16 days, respectively. The descriptive mean difference was −4.4 days, corresponding to a 39.3% shorter mean duration relative to conventional therapy. No new significance test was performed. Laboratory tables suggested recovery of selected salivary defense markers and decreases in endothelial injury markers, although inconsistencies prevented definitive comparative inference.

Conclusions: Adjunctive film and laser therapy was associated with shorter reported epithelialization time in this cohort. The findings are preliminary and do not establish causality or the independent contribution of either component. Verification of the treatment protocol and original data is necessary before submission and further controlled evaluation.

Keywords:

References

Fitzpatrick SG, Cohen DM, Clark AN. Ulcerated lesions of the oral mucosa: clinical and histologic review. Head Neck Pathol. 2019;13(1):91–102. doi:10.1007/s12105-018-0981-8.

AlHerafi E, Hamadah O, Parker S. Photobiomodulation in recurrent aphthous stomatitis management using three different laser wavelengths. A randomized clinical trial. Lasers Med Sci. 2024;39(1):285. doi:10.1007/s10103-024-04236-3.

Bardellini E, Veneri F, Amadori F, Conti G, Majorana A. Photobiomodulation therapy for the management of recurrent aphthous stomatitis in children: clinical effectiveness and parental satisfaction. Med Oral Patol Oral Cir Bucal. 2020;25(4):e549–e553. doi:10.4317/medoral.23573.

Robijns J, Nair RG, Lodewijckx J, et al. Photobiomodulation therapy in management of cancer therapy-induced side effects: WALT position paper 2022. Front Oncol. 2022;12:927685. doi:10.3389/fonc.2022.927685.