The Impact of HbA1C level on FSH and LH Changes during menopausal Transition in Diabetes Women

Abstract

Diabetes mellitus (DM) is a prevalent endocrine disorder characterized by prolonged elevation of blood glucose levels. Hemoglobin A1c (HbA1c) serves as a critical metric for assessing mean glycemic control in individuals with diabetes. In this study, we aimed to explore the impact of diabetic control, measured by HbA1c levels, on pituitary gonadotropins (FSH and LH) in Iraqi women with Type 2 diabetes during the menopausal transition. A cross-sectional study involving one hundred diabetic menopausal women aged between 45 and 60 years was conducted from November 2023 to March 2024. Participants were categorized into groups based on HbA1c values indicating good or poor glycemic control. Data on various variables including age, height, weight, BMI, fasting blood sugar, HbA1c, FSH, and LH were collected and analyzed. Our findings revealed no significant difference in LH or FSH levels among diabetic women with varying degrees of HbA1c control. Spearman's rho correlation coefficients showed weak negative correlations between HbA1c and both LH and FSH levels. These results underscore the complex interplay between glycemic control, hormonal regulation, and metabolic factors in diabetic women during the menopausal transition.

Keywords:

Diabetes mellitus, Menopausal transition, HbA1C, FSH, LH

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