Comparatives Analysis of Inflammatory and Biochemical Markers in Dialysis Patients: The Impact of Age and Sex

Abstract

Dialysis is a medical procedure that replaces the kidneys when they are unable to function normally. It helps to keep the blood's chemical balance safe by eliminating waste, extra fluid, and toxins. Haemodialysis and peritoneal dialysis are the two primary varieties.  A total of 50 patients were enrolled between August and December 2024. Blood samples were collected to assess kidney function through blood urea, serum creatinine, glucose, and estimated glomerular filtration rate (GFR). Inflammatory biomarkers Monocyte Chemoattractant Protein-1 (MCP-1) and E-selectin were measured using ELISA. Blood pressure readings were also recorded. The results revealed that Analyzes compared differences based on sex and across age groups (16–32, 33–48, 49–64, and 65–80 years) using one‐sample t‐tests, independent samples t‐tests, and one‐way ANOVAs.

Significant differences were observed particularly in MCP-1 between females and males, while analyzes of age groups revealed modest trends with low variance explained. These findings support the need for personalized monitoring strategies that consider sex as a key factor in the management of dialysis patients.

Keywords:

Dialysis, inflammatory markers, MCP-1, E-selectin, biochemical parameters, sex differences, age groups

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