The effect of minor thalassemia on the liver function and lipid profile compared with major thalassemia

Abstract

It is thought that only patients with major thalassemia need to be under healthy control compared to minor. Thus, the aim of this work is to investigate the minor thalassemia complications in the liver status and compare them with the major thalassemia. So, 84 patients with thalassemia were randomly selected; 56 with major and 28 with minor. The Blood Samples were collected and used to determine the levels of ferritin, liver enzymes and lipid profiles. The results were showed that while there were no significantly differences in the ALP levels, ALT and AST levels were significantly higher in the major thalassemia compared to minor. All the patients with major and minor had abnormal higher ALP, 45% of major had abnormal higher AST and 30% of the major had abnormal ALT than normal range. BilD, BilT, cholesterol and trig levels were significantly higher while LDH and UHDL levels were significantly lower in the major compared to minor. The BilD levels in 90% of the major compared to 40% of the minor were abnormal higher than normal range. As conclusion, there were abnormality in the ALP and some lipid profile of minor thalassemia. So, the patients with minor thalassemia could be under risk of liver disorder so they need to be under control and to find the exact reason of this disorder need more researches. 

Keywords:

Ferritin, liver enzymes, lipid profiles, Thalassemia

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DOI: http://dx.doi.org/10.18203/2349-3291.ijcp20170706.

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