Comparative Study of frozen Section with Histopathology of Primary Site in OSCC

Abstract

Background: Oral squamous cell carcinoma (OSCC) is largely a disease of older adults, occurring most commonly in patients older than age 45. Surgery was a principal modality of treatment and gaining microscopically negative resected margins are possible the most significant prognostic factor for a patient with a head and neck squamous cell carcinoma (HNSCC) and accordingly Frozen section (FS) evaluation was used to confirm negative margins. Aim of study: To compare the accuracy of frozen section FS with permanent histological examination of the same primary site margins and to improve the validity of FS during intra-operative operations. Methods: The researchers reviewed frozen section examination of the resection surfaces of 13 patients surgically treated for oral squamous cell carcinoma during the period October 2020 to October 2021 when close or positive margins was present at the resection surface, re-resection 0.5 cm was performed. Then after final histopathological study obtained, we compare it with FS result to evaluate the accuracy of FS. Results: A total of 39 margins were evaluated from 13 individuals. With a p value of 0.001, all margins exhibited highly significant concordance with the permanent section of the same tissue sample. Conclusion: Frozen section histopathological study data, sensitivity, specificity and accuracy, showed highly significant p value result which improve its validity intraoperatively this result was confirmed by permanent histopathological study.

Keywords:

OSCC, HNSCC, FS Evaluation, CAL, BOP, PI, GI

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